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US 2023/0056900 A1Published application
Fc VARIANTS THAT IMPROVE FcRn BINDING AND/OR INCREASE ANTIBODY HALF-LIFE
AssigneeXencor, Inc.
InventorGregory Alan Lazar
Life of this patent
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Abstract
The present invention discloses the generation of novel variants of Fc domains, including those found in antibodies, Fc fusions, and immuno-adhesions, which have an increased binding to the FcRn receptor and/or increased serum half-life.
Claims6
-6. (canceled)
An antibody comprising:
- a) a light chain at least about 95% identical to SEQ ID NO:77;
- and
- b) a heavy chain at least about 95% identical to SEQ ID NO:76,
- wherein said antibody binds to human CD20, and wherein said heavy chain comprises S239D and I332E amino acid substitutions according to EU numbering.
1 more element
Dependencies are inferred from the claim text.