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US 2023/0056857 A1Published application
Nanosystems for controlled transport of active molecules for diagnostic, prognostic and therapeutic purposes
AssigneesFidia Farmaceutici S.P.A., Nanogetic S.L.
InventorsRosario Maria SANCHEZ MARTIN, Salvatore PERNAGALLO, Juan Diego UNCITI BROCETA, Luciano MESSINA, Susanna VACCARO, Laura PILOTTO
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Abstract
Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
Claims10
A nanoparticle system, comprising:
- polystyrene nanoparticles wherein the nanoparticles are 200 nm in size and covalently bonded to a heterocarbon chain;
- and
- a hyaluronidase;
- wherein the polystyrene nanoparticles covalently bonded to a heterocarbon chain are formed by reacting amino-functionalized polystyrene nanoparticles with N-Fmoc-N″-succinyl-4,7,10-trioxa-1,13-tridecanediamine to covalently bond primary amines on the polystyrene to functional groups on the heterocarbon chain;
- wherein the hyaluronidase is recombinant hyaluronidase rHyal_Sk;
- and
- wherein the recombinant hyaluronidase rHyal_Sk is bonded to the heterocarbon chain via diethyl squarate.
4 more elements
A nanoparticle system, comprising:
- polystyrene nanoparticles, wherein the nanoparticles are 200 nm in size and covalently bonded to a heterocarbon chain;
- and
- a hyaluronidase;
- wherein the polystyrene nanoparticles covalently bonded to a heterocarbon chain are formed by reacting amino-functionalized polystyrene nanoparticles with N-Fmoc-N″-succinyl-4,7,10-trioxa-1,13-tridecanediamine to covalently bond primary amines on the polystyrene to functional groups on the heterocarbon chain;
- wherein the hyaluronidase is recombinant hyaluronidase rHyal_Sk;
- wherein the recombinant hyaluronidase rHyal_Sk is bonded to the heterocarbon chain via diethyl squarate;
- and
- wherein the heterocarbon chain does not contain a free charge.
5 more elements
Dependencies are inferred from the claim text.