Mucoadhesive solid or semisolid ocular delivery systems based on preactivated thiomers
AssigneeBioadhesive Ophthalmics
InventorJean GARREC
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Abstract
A mucoadhesive solid or semisolid ocular delivery systems that includes a matrix of preactivated thiomers, preferably under the form of ocular inserts or ocular films. The ocular delivery systems are useful for ocular drug delivery for the treatment of ocular diseases. The delivery systems of the invention can also be used for alleviating ocular conditions such as dry eye syndrome.
Claims20
-12. (canceled)
A mucoadhesive solid or semisolid ocular delivery system comprising a preactivated thiomer matrix, wherein the matrix comprises at least one preactivated thiomer selected from polymeric compounds bearing 2-mercaptonicotinic acid, 6-mercaptonicotinic acid, 2-mercaptonicotinamide, 2-mercaptoisonicotinamide, 6-mercaptonicotinamide, 6-mercaptoisonicotinamide, 6,6′-dithionicotinamide or 6-mercaptopyridoxine side chains covalently bonded through disulfide bonds to a thiolated polymer backbone.
A method for the manufacturing of a mucoadhesive solid or semisolid ocular delivery system, comprising forming the mucoadhesive solid or semisolid ocular delivery system from a preactivated thiomer, wherein the preactivated thiomer is selected from polymeric compounds bearing 2-mercaptonicotinic acid, 6-mercaptonicotinic acid, 2-mercaptonicotinamide, 2-mercaptoisonicotinamide, 6-mercaptonicotinamide, 6-mercaptoisonicotinamide, 6,6′-dithionicotinamide or 6-mercaptopyridoxine side chains covalently bonded through disulfide bonds to a thiolated polymer backbone.
The method according to claim 12, wherein the mucoadhesive solid or semisolid ocular delivery system is an ocular insert or an ocular film.
Dependencies are inferred from the claim text.