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US 2023/0056541 A1Published application
Egfr inhibitors
AssigneeBlueprint Medicines Corporation
InventorsJohn Emmerson Campbell, Thomas A. Dineen, Natasja Brooijmans, Jason D. Brubaker, Meredith Suzanne Eno, Joseph L. Kim, Aysegül Özen, Emanuele Perola, Brett D. Williams, Douglas Wilson, Kevin J. Wilson, Christopher De Savi
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Abstract
The present disclosure provides a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.
Claims22
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Z is O or NH;
- each A1, A2, and A3 is independently N or CR;
- wherein each R is independently H, halogen, or CH3;
- Ring A is 4-12 membered heterocyclyl;
- each R1 is independently halogen, CN, OH, NRaRb, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl or —O—C3-C6 cycloalkyl, wherein the alkyl, alkoxy or cycloalkyl represented by R1 or in the group represented by R1 is optionally substituted with 1 to 3 groups selected from deuterium, halogen, OH, NRaRb, C1-C2 alkyl, and C1-C2 alkoxy;
- and/or
- m is 0, 1, 2, 3, 4, 5, or 6;
- R2 is H, halogen, C1-C4 alkyl, C1-C4 alkoxy, or C3-C6 cycloalkyl, wherein the alkyl, alkoxy or cycloalkyl represented by R2 is optionally substituted with 1 to 3 groups selected from halogen and OH;
- R3 is H or methyl;
- R4 is H or methyl;
- R5 is H, C1-C4 alkyl, C3-C6 cycloalkyl or 4-6 membered monocyclic heterocyclyl, wherein the alkyl, cycloalkyl or heterocyclyl represented by R5 is optionally substituted with 1 to 3 three groups selected from halogen, CN, OH, NRaRb, C1-C2 alkyl, and C1-C2 alkoxy;
- R6 is H or C1-C4 alkyl optionally substituted with 1 to 3 three groups selected from halogen, CN, OH, NRaRb, and C1-C2 alkoxy;
- and
- each Ra and Rb is independently H or C1-C4 alkyl.
12 more elements
21-25. (canceled)
Dependencies are inferred from the claim text.