Polypeptides
AssigneeSorriso Pharmaceuticals, Inc.
InventorsScott CROWE, Mike WEST, Kevin ROBERTS, Tim CARLTON, Luana MAGGIORE, Marion CUBITT, Lurdes DUARTE, Martyn SYMMONS, Keith RAY
Life of this patent
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Abstract
There are provided inter alia polypeptides capable of inhibiting IL-7 and/or L-TSLP binding to IL-7R (IL-7R), as well as to constructs and pharmaceutical compositions comprising these polypeptides.
Claims29
A method of treating an autoimmune or inflammatory disease, the method comprising administering to an individual a polypeptide capable of inhibiting IL-7 and/or L-TSLP binding to wherein the polypeptide comprises an immunoglobulin chain variable domain which binds to IL-7Rα comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 71, or 82 a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 72, 73, 74, 75, 76, or 83 and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 77, 78, or 84, thereby treating the autoimmune or inflammatory disease.
The polypeptide according to clause 1, wherein the polypeptide is capable of inhibiting IL-7 binding to IL-7R.
The polypeptide according to clause 1, wherein the polypeptide is capable of inhibiting L-TSLP binding to IL-7R.
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Dependencies are inferred from the claim text.