Blood-brain-barrier systems
AssigneeB. G. Negev Technologies and Applications Ltd., At Ben-Gurion University
InventorsGad David VATINE, Roman KHOURIN
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Abstract
Disclosed herein is a device comprising a microelectrode comprising cells cultured on a surface of the microelectrode and a porous membrane comprising an upper surface comprising cultured cells. Further, devices and methods for in in-vitro models of the blood-brain barrier (BBB) and for modeling the transport across this barrier are disclosed.
Claims23
A device comprising:
- i. a microelectrode comprising cells cultured on a surface of said microelectrode;
- and
- ii. a porous membrane comprising an upper surface comprising cultured cells and a lower surface;
- wherein:
- said porous membrane is positioned above said microelectrode and said cells cultured on said microelectrode are facing said lower surface of said porous membrane.
-5. (canceled)
(canceled)
-14. (canceled)
A method for differentiating induced pluripotent stem cells (iPSCs) to brain microvascular endothelial cells (BMECs), wherein said iPSCs are cultured in serum free medium, thereby differentiating said iPSCs to BMECs.
Dependencies are inferred from the claim text.