Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3h)-dione analogues

A method of treating dengue disease comprising administering a Dengue NS4B specific inhibitor to a subject having dengue disease, wherein the Dengue NS4B specific inhibitor is a compound chosen from:

• (a) a compound of Formula (I), wherein:
• wherein:
• R1, R2 are independently chosen from H, F, Cl, Br and CF3;
• R3 is F, Cl or Br;
• R4 is F, Cl, Br, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, carboxyl, ester, acetal, amino, 5-membered cycle or heterocycle, or 6-membered cycle or heterocycle;
• R5 is H or alkyl;
• X, Y are independently chosen from CH and N;
• and
• linker is a 1-20 atom length carbon chain or, wherein said chain optionally includes one or more ester bonds, amide bonds or oxygen atoms;
• or
• (b) a compound of Formula (Ib), wherein:
• wherein R6, R7 are independently chosen from H, alkyl;
• or R7, R8 taken together with other atoms to form 5-membered or 6-membered heterocycle rings;
• and n is 1-10;
• or
• (c) a compound of formula (Ic), wherein:
• wherein R8, R9 are independently chosen from H, alkyl, alkoxy, F, Cl, Br, CF3, hydroxyl, carboxyl, ester, cyano, amino, nitro, or R9, R10 taken together with the atoms to which they are attached form 5-membered or 6-membered fused ring;
• X1, X2, X3 are independently chosen from CH and N;
• and n is 1-10;
• or
• (d) a compound represented by:
• wherein R10 is chosen from
• n is 1-10;
• or
• (e) a compound represented by:
• wherein R11 is chosen from
• wherein linker is a 1-20 atom length carbon chain, wherein said chain optionally includes one or more ester bonds, amide bonds or oxygen atoms;
• or
• (f) a compound of Formula (II)
• wherein X4, X5 are independently chosen from F, Cl, Br, and CF3, and
• R12, R13 are 1-20 atom length carbon chain;
• wherein said chain optionally includes one or more ester bonds, amide bonds or oxygen atoms
• R13 is H.