Combined local delivery of therapeutic agents using interventional devices and radiation

A delivery system for local drug delivery to a target site of internal body tissue, comprising:

• a source electrode adapted to be positioned proximate to the target site of internal body tissue, the source electrode comprising an array of probes terminating at different lengths and being independently powered such that the probes are capable of being variably controlled;
• a counter electrode in electrical communication with the source electrode, the counter electrode being configured to cooperate with the source electrode to form a localized electric field proximate to the target site, wherein the counter electrode includes an ion selective membrane disposed at least partially thereabout for limiting interference of non-cargo ions with the cargo to be delivered to the target site;
• a reservoir capable of interacting with the localized electric field, the reservoir being configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field formed between the source electrode and the counter electrode;
• and
• a radiation source external to the body and configured to apply a radiation to the target site.

A method of delivering a cargo to a target site of internal body tissue, the method comprising:

• disposing a source electrode proximate to a target site of internal body tissue in vivo, the source electrode comprising an array of probes terminating at different lengths and being independently powered such that the probes are capable of being variably controlled;
• disposing a counter electrode in electrical communication with the source electrode, the counter electrode being configured to cooperate with the source electrode to form a localized electric field proximate to the target site;
• disposing a reservoir such that the reservoir is capable of interacting with the localized electric field, the reservoir being configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field formed between the source electrode and the counter electrode;
• applying a voltage potential across the source and counter electrodes to form an electric field, thereby delivering at least a portion of the cargo to the target site;
• and
• applying a radiation to the target site from a radiation source external to the body.