C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors

A method of treating cancer comprising administering to the subject a therapeutically effective amount of either a compound or a composition selected from the group consisting of

• (1) a compound having the formula
• or a stereoisomer thereof;
• (2) a compound having the formula
• or a tautomer thereof;
• (3) a compound having the formula
• (4) a compound having the formula
• or a stereoisomer thereof;
• (5) a compound having the formula
• or a tautomer thereof;
• (6) a compound having the formula
• (7) a compound having the formula
• (8) a composition comprising a mixture of
• or a stereoisomer or tautomer thereof
• and
• or a stereoisomer or tautomer thereof;
• and
• (9) a composition comprising a mixture of
• and