Pharmaceutical composition containing b-lapachone as active ingredient for prevention or treatment of cholestatic liver disease
AssigneeCurome Biosciences Co., Ltd.
InventorsJoo Seog YOON, Kang Sik SEO, Jeong Su HAN, Sung Je MOON, Jung Hoon LEE, Soo Bin YOON
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Abstract
The present invention relates to a pharmaceutical composition containing β-lapachone as an active ingredient for prevention or treatment of cholestatic liver disease, and can provide agents for effectively preventing and treating cholestatic liver disease.
Claims20
A pharmaceutical composition for prevention or treatment of cholestatic liver disease, the pharmaceutical composition containing β-lapachone or a pharmaceutically acceptable salt thereof as an active ingredient.
A health functional food for prevention or amelioration of cholestatic liver disease, the heath functional food comprising β-lapachone or a pharmaceutically acceptable salt thereof as an active ingredient.
A method for prevention or treatment of cholestatic liver disease, comprising administering to a mammal in need thereof a therapeutically effective amount of a pharmaceutical composition containing β-lapachone or a pharmaceutically acceptable salt thereof as an active ingredient.
The method of claim of 15, wherein the inhibiting of inflammation comprises inhibiting at least one selected from inflammatory cytokine factors consisting of interleukin-1beta (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), interferon-γ (INF-γ), tumor necrosis factor-α (TNF-α), tumor necrosis factor-β (TNF-β), and monocyte chemoattractant protein-1 (MCP-1).
Dependencies are inferred from the claim text.