Formulations of creatine and cyclodextrin exhibiting improved bioavailability
AssigneePhenolics, LLC
InventorsMichael S. Tempesta, F. Joseph Daugherty
Life of this patent
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Abstract
Formulations of creatine, preferably phosphocreatine and most preferably disodium phosphocreatine, combined with cyclodextrin exhibit improved uptake across digestive mucosa, including intestinal, esophageal, and stomach mucosa. In particular, the formulations of the present invention are designed for protection of the creatine as they come in contact with gastric juices so as to allow thereafter for unexpectedly improved site-specific intestinal release.
Claims20
A method of manufacturing a creatine supplement comprising:
- co-granulating one or more creatine compounds, cyclodextrin, and a sodium source to form a granular composition having an average particle size of from 150 to 850 microns;
- and
- coating the granular composition with methacrylate copolymers to produce a coated creatine supplement.
A method of manufacturing a creatine supplement comprising:
- co-granulating a plurality of the following:
- (i) one or more creatine compounds;
- (ii) cyclodextrin;
- or
- (iii) a sodium source;
- forming a granular composition having an average particle size of from 150 to 850 microns;
- and
- coating the granular composition with methacrylate copolymers to produce a coated creatine supplement.
A method of manufacturing a creatine supplement comprising:
- co-granulating a plurality of the following:
- (i) creatine monohydrate, creatine HCL and/or phosphocreatine;
- (ii) cyclodextrins selected from the group consisting of alpha, beta and gamma cyclodextrins;
- or
- (iii) a sodium source;
- forming a granular composition having an average particle size of from 150 to 850 microns;
- and
- coating the granular composition with methacrylate copolymers to produce a coated creatine supplement.
Dependencies are inferred from the claim text.