Methods for inducing biostasis in a cell, tissue or organ
AssigneesPresident and Fellows of Harvard College, Trustees of Tufts College
InventorsTakako TAKEDA, Megan Sperry, Erica Gardner, Michael Levin, Charles Reilly, Richard Novak, Donald E. Ingber
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Abstract
Provided herein are methods for promoting biostasis or preservation of a cell, tissue or organ during cancer treatment or for transplantation comprising contacting the cell, tissue or organ with an agonist of the δ-opioid receptor, SNC-80, an or Donepezil. Further provided herein is a method of treating a hematological neoplastic disease.
Claims27
A method of inducing biostasis in a tissue or organ, the method comprising contacting the tissue or organ in need of preservation with an agent that alters the function of at least one ion channel selected from the group consisting of EAAT1 ion channel and NCX1 ion channel, wherein the contacted tissue or organ exhibits biostasis.
A method of tissue or organ transplant, the method comprising contacting a donor tissue or organ in situ or ex vivo with an agent that alters the function of at least one ion channel selected from the group consisting of EAAT1 ion channel and NCX1 ion channel.
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A composition comprising at least two agents that alter the function of at least one ion channel selected from the group consisting of EAAT1 ion channel and NCX1 ion channel.
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Dependencies are inferred from the claim text.