Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin
AssigneeGenemedicine Co., Ltd.
InventorsChae-Ok YUN, Joo-Hang KIM
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Abstract
The present invention relates to a novel gene delivery system and recombinant adenovirus including the relaxin-encoding sequence to enhance transduction efficiency of transgenes, a pharmaceutical anti-tumor composition including the recombinant adenovirus, a pharmaceutical composition having improved tissue penetration potency and a pharmaceutical composition for treating a disease or disorder associated with accumulation of excess extracellular matrix.
Claims13
1-3. (canceled)
A gene delivery system comprising a relaxin-encoding nucleotide sequence to enhance a transduction efficiency of the nucleotide sequence of interest into the cell.
A recombinant adenovirus, comprising an adenoviral ITR (inverted terminal repeat) nucleotide sequence and a relaxin-encoding nucleotide sequence, wherein a relaxin protein expressed from the relaxin-encoding nucleotide sequence enhances a penetration potency of the recombinant adenovirus into a tumor tissue and apoptosis of a tumor cell infected with the recombinant adenovirus.
Dependencies are inferred from the claim text.