Fusokines involving cytokines with strongly reduced receptor binding affinities
AssigneesVib Vzw, Universiteit Gent, Centre National de le Recherche Scientifique, Universite De Montpellier, Centre Hospitalier Regional Universitaire De Montpellier
InventorsJan TAVERNIER, Jennyfer BULTINCK, Sarah GERLO, Gilles UZE, Franciane PAUL, Yann BORDAT
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Abstract
The present invention relates to a fusion protein comprising at least two cytokines, of which at least one is a modified cytokine with a strongly reduced binding affinity to its receptor, or to one of its receptors. Preferably, both cytokines are connected by a linker, preferably a GGS linker. The invention relates further to said fusion protein for use in treatment of diseases.
Claims8
A fusion protein comprising at least two cytokines, of which at least one cytokine is modified in such a way that it has a strongly reduced binding activity to its receptor,
(canceled)
Dependencies are inferred from the claim text.