Composition and methods of manufacture

A composition comprising one or more isolated proteolytically active serine proteases extracted from ripe fruit of Carica papaya.

A composition comprising a mixture of one or more proteolytically active serine proteases and one or more active cysteine proteases extracted from ripe fruit of Carica papaya.

A composition comprising a mixture of one or more isolated proteolytically active serine proteases and one or more active cysteine proteases extracted from ripe fruit of Carica papaya.

A process for preparing a composition comprising a proteolytically active serine protease, wherein the process comprises treating pulped ripe fruit of Carica papaya with an alkali, without subjecting the pulped ripe fruit to a heating step, and separating soluble protease from insoluble plant material after the alkali treatment.

A pharmaceutical composition comprising a proteolytically active Carica papaya serine protease together with a pharmaceutically acceptable carrier or diluent, wherein the serine protease is extracted from ripe fruit of Carica papaya.

A pharmaceutical composition comprising an isolated proteolytically active Carica papaya serine protease together with a pharmaceutically acceptable carrier or diluent, wherein the serine protease is extracted from ripe fruit of Carica papaya.

A cosmetic composition comprising a proteolytically active Carica papaya serine protease together with a cosmetically acceptable carrier or diluent, wherein the serine protease is extracted from ripe fruit of Carica papaya.

A cosmetic composition comprising an isolated proteolytically active Carica papaya serine protease together with a cosmetically acceptable carrier or diluent, wherein the serine protease is extracted from ripe fruit of Carica papaya.