7-, 8-, and 10-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE

A compound having a structural Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from H, F, Cl, Br, CN, OH, (C1-C6)alkyl, O(C1-C6)alkyl, and O(C1-C6)haloalkyl;
• R2 is selected from H, F, Cl, Br, CN, OH, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, O(C1-C6)haloalkyl, (C3-C4)cycloalkyl, S(O)2(C1-C6)alkyl, S(O)2(C1-C6)haloalkyl, and 4-5 membered monocyclic heterocycloalkyl comprising 1 or 2 ring nitrogen atoms;
• R4 is selected form H, F, Cl, Br, (C1-C6)alkyl, and (C1-C6)haloalkyl,
• with the proviso that at least one of R1, R2, or R4 is not H;
• and
• ring A is a moiety selected from:
• wherein:
• R3 is selected from:
• pyrazolyl, pyridinyl, pyrazinyl, phenyl, oxadiazolyl, thiazolyl, triazolyl, pyrimidinyl, pyridazinyl, and imidazolyl,
• wherein said pyridinyl, said pyrazinyl, and said phenyl are substituted with 1, 2, 3, or 4 R3A groups
• wherein said pyrazolyl, pyridazinyl, imidazolyl, and said pyrimidinyl are substituted with 1, 2, or 3 R3A groups,
• wherein said triazolyl and said thiazolyl are substituted with 1 or 2 R3A groups, and
• wherein said oxadiazolyl is substituted with 1 R3A group;
• each R3A is independently selected from H, F, Cl, (C1-C6)alkyl, (C1-C6)alkyl-OH, (C1-C6)haloalkyl, (C1-C6)alkylNH2, O(C1-C6)alkyl, O(C1-C6)haloalkyl, C(O)(C1-C3)alkyl, (C1-C4)alkylC(O)(C1-C3)alkyl, (C1-C4)alkylO(C1-C3)alkyl, (C1-C4)alkylCH(OH)(C1-C3)alkyl, (C1-C4)alkylS(O)2(C1-C3)alkyl, (C1-C6)alkylC(O)NH(C1-C6)alkyl, (C1-C6)alkylC(O)OH, (C1-C6)alkylC(O)NH(C3-C6)cycloalkyl,
• —(CH2)n(C3-C7)cycloalkyl, and —(CH2)n4-7 membered monocyclic heterocycloalkyl comprising 1 or 2 ring heteroatoms selected from O, N, S, and S(O)2,
• wherein said (C3-C7)cycloalkyl, and said 4-7 membered monocyclic heterocycloalkyl are each unsubstituted or substituted with 1, 2, or 3 groups independently selected from F, Cl, OH, oxo, (C1-C6)alkyl, O(C1-C6)alkyl, (C1-C6)haloalkyl, and O(C1-C6)haloalkyl;
• n is 0, 1, or 2;
• each R3Aa is independently selected from H, (C1-C4)alkyl, O(C1-C4)alkyl, (C1-C4)haloalkyl, O(C1-C4)haloalkyl, and (C3-C4)cycloalkyl;
• RA1 is selected from H, and (C1-C4)alkyl;
• each RA2 is independently selected from H, F, and (C1-C4)alkyl;
• RA3 is selected from H, F, and (C1-C4)alkyl;
• RA4 is selected from H and OH;
• and
• RA5 is selected from H, F, and (C1-C4)alkyl.