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US 2023/0054375 A1Published application
Anti-cd47 antibody and uses thereof
AssigneeThe UAB Research Foundation
InventorXiaoguang Margaret LIU
Life of this patent
Estimating the term…
Abstract
Disclosed herein is an antibody that selectively binds CD47 on tumor cells. Also disclosed is a method for treating cancer in a subject, comprising administering to the subject an effective amount of the antibody disclosed herein.
Claims12
An antibody that selectively binds CD47 on tumor cells, comprising a variable heavy (VH) domain having CDR1, CDR2 and CDR3 sequences and a variable light (VL) domain having CDR1, CDR2 and CDR3 sequences, wherein
- the CDR1 sequence of the VH domain comprises the amino acid sequence FTFNTYAMN (SEQ ID NO:5), the CDR2 sequence of the VH domain comprises the amino acid sequence WIARIRSKSNNYATYY (SEQ ID NO:6), the CDR3 sequence of the VH domain comprises the amino acid sequence RPAQGAMDY (SEQ ID NO:7), the CDR1 sequence of the VL comprises the amino acid sequence QRISNNLH (SEQ ID NO:8), the CDR2 sequence of the VL domain comprises the amino acid sequence LLIKYSSQSIS (SEQ ID NO:9), and the CDR3 sequence of the VL domain comprises the amino acid sequence QQSNAWPY (SEQ ID NO:10).
Dependencies are inferred from the claim text.