Non-aqueous sustained release drug delivery system

A non-aqueous sustained release drug delivery system, comprising:

• an active agent, a drug solvent, a drug sustained release agent, a drug solubilizer, an efficacy enhancer, an optional antioxidant, and an optional acid-base regulator, wherein,
• the drug solvent is one or more selected from the group consisting of benzyl alcohol, ethanol, glycerol, isopropanol, liquid polyethylene glycol, polyethylene glycol monomethyl ether, glycerol monoacetate, diethylene glycol monoethyl ether, ethyl lactate, tetrahydrofuran polyethylene glycol ether, benzyl benzoate, dimethyl acetamide, N-methyl pyrrolidone, 2-pyrrolidone, propylene glycol, methyl acetate, ethyl acetate, propylene glycol diacetate, diethyl malonate, glyceryl triacetate, dimethylformamide, dimethyl sulfoxide, caprolactam, triethyl citrate, and propylene carbonate,
• the drug sustained release agent is one or more selected from the group consisting of biodegradable polymers and pharmaceutical oils,
• the drug solubilizer is one or more selected from the group consisting of pharmaceutical surfactants,
• the efficacy enhancer is one or more selected from the group consisting of ω-3 fatty acids and metabolites thereof, substances rich in ω-3 fatty acids or metabolites thereof, glucocorticoids, and phosphodiesterase-4 inhibitors,
• the antioxidant is one or more selected from the group consisting of cysteine, α-tocopherol, α-tocopherol acetate, N-acetyl-L-cysteine, butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, tert-butyl hydroquinone, lipoic acid, tea polyphenols, L-ascorbyl palmitate, glutathione, and
• the acid-base regulator is one or more selected from the group consisting of arginine, lysine, histidine, glycine, tromethamine, diethanolamine, ethylenediamine, meglumine, hydrochloric acid, acetic acid, anhydrous citric acid, ascorbic acid, lactic acid, tartaric acid, methanesulfonic acid, methionine, sodium hydroxide, and triethanolamine.