Pd-l1 antagonist compound

A compound of formula (I) or a pharmaceutically acceptable salt thereof, a prodrug, an isotopic derivative, an isomer, a solvate, or a metabolite thereof

• wherein L1 is selected from —CRARB—and —C(O)—;
• L2, L3 is selected from —(CRCRD)p, —(CRCRD)pNRa—(CRCRD)q—, —(CRCRD)p—O—(CRCRD)q— and —C(O)—;
• W1, W2 each independently represents CRL or N;
• R1 each independently represents hydrogen, halogen, nitro, cyano or —NRaRb, or C1-C6 alkyl, C3-C6 cycloalkyl, —O(C1-C6 alkyl), —O(C0-C6 alkylene)(C3-C6 cycloalkyl) or —O(C0-C6 alkylene)(3-6 membered heterocycloalkyl) substituted with 0, 1, 2 or 3 substituents;
• wherein the substituents are selected from —ORa, cyano, oxo, halogen, C1-C6 alkyl, —(C1-C6 alkylene)ORa, cyano C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, —C(O)Ra, —(C1-C6 alkylene)C(O)Ra, —C(O)ORa, —(C1-C6 alkyl)C(O)ORa, —NRaRb, —(C1-C6 alkylene)NRaRb, —C(O)NRaRb, —SO2Ra, —C(O)NRaSO2Rb and —NRaC(O)Rb;
• R2, R3, R4, R5 each independently represent hydrogen, halogen, nitro, cyano, —NRaRb, —SO2Ra, —S(O)Ra, —P(O)RaRb, C1-C6 alkyl, —O(C1-C6 alkyl), —O(C3-C6 cycloalkyl), halo(C1-C6 alkyl) or C3-C6 cycloalkyl;
• Cy represents benzene ring or six-membered heteroaryl substituted by 0, 1, 2 or 3 R6, wherein the six-membered heteroaryl may optionally contain 1 or 2 nitrogen atoms;
• wherein the R6 represents hydrogen, halogen, nitro, cyano, —NRaRb, —SO2Ra, —S(O)Ra or —P(O)RaRb or C1-C6 alkyl, C3-C6 cycloalkyl, —O(C1-C6 alkyl), —O(C0-C6 alkylene)(C5-C10 aryl), —O(C0-C6 alkylene)(5-10 membered heteroaryl), —O(C0-C6 alkylene)(C3-C6 cycloalkyl) or —O(C0-C6 alkylene)(3-6 membered heterocycloalkyl) substituted with 0, 1, 2 or 3 substituents;
• wherein the substituents are selected from —ORa, cyano, oxo, halogen, C1-C6 alkyl, —(C1-C6 alkylene)ORa, cyano C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, —C(O)Ra, —(C1-C6 alkylene)C(O)Ra, —C(O)ORa, —(C1-C6 alkylene)C(O)ORa, —NRaRb, —(C1-C6 alkylene)NRaRb, —C(O)NRaRb, —SO2Ra, —C(O)NRaSO2Rb or —NRaC(O)Rb;
• wherein RL represents hydrogen, C1-C6 alkyl, —O(C1-C6 alkyl), —O(C3-C6 cycloalkyl), halogen, nitro, cyano, —NRaRb, halo(C1-C6 alkyl) or C3-C6 cycloalkyl;
• T, A each independently represent —(C1-C6 alkyl), —(C0-C6 alkylene)-(C3-C12 cycloalkyl), —(C0-C6 alkylene)-(3-12 membered heterocycle), —(C0-C6 alkylene)-(C6-C10 aryl) or —(C0-C6 alkylene)-(5-10 membered heteroaryl) substituted with 0, 1, 2 or 3 substituents, wherein the substituents are selected from cyano, oxo, halogen, C1-C6 alkyl, —(C0-C6 alkylene)ORa, cyano C1-C6 alkyl, halo(C1-C6 alkyl), C3-C8 cycloalkyl, —(C0-C6 alkylene)C(O)Ra, —(C0-C6 alkylene)C(O)ORa, —(C0-C6 alkenyl)C(O)ORa, —(C0-C6 alkylene)NRaRb, —C(O)NRaRb, —NRaSO2Rb, —C(O)NRaSO2Rb and —NRaC(O)Rb;
• wherein RA, RB each independently represent hydrogen, C1-C6 alkyl, —(C0-C3 alkylene)(C3-C12 cycloalkyl), —(C0-C3 alkylene)(3-12 membered heterocycle), halo(C1-C6 alkyl) or halogen, or RA and RB together with their co-attached carbon atom form a 3-6 membered ring;
• RC, RD each independently represent hydrogen, C1-C6 alkyl, —(C0-C3 alkylene)(C3-C12 cycloalkyl), —(C0-C3 alkylene)(3-12 membered heterocycle), halo(C1-C6 alkyl) or halogen, or RC and RD together with their co-attached carbon atom form a 3-6 membered ring;
• Ra, Rb each independently represent hydrogen, C1-C6 alkyl, halo(C1-C6 alkyl), —(C0-C6 alkylene)OH, —(C0-C3 alkylene)(C3-C12 cycloalkyl), —(C0-C3 alkylene)(3-12 membered heterocycle), —(C0-C3 alkylene)(C6-C10 aryl), —(C0-C3 alkylene)(5-10 membered heteroaryl) or halo(C1-C6 alkyl), or Ra and Rb together with their co-attached atom form a 3-6 membered ring;
• wherein m, o each independently represent 0, 1 or 2;
• and
• wherein p, q each independently represent 0, 1, 2 or 3.