Liquid nimodipine compositions
AssigneeAzuirty Pharmaceuticals, LLC
InventorHugh Greg Thomas
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Abstract
Liquid compositions comprising nimodipine having improved nimodipine concentrations are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the liquid compositions of the present invention are also detailed herein.
Claims15
-14. (canceled)
A liquid composition comprising nimodipine and a solvent system from about 50% to about 97% (w/v) polyethylene glycol (PEG), about 1% to about 35% (w/v) water, from about 0.5% to about 5% (w/v) ethanol, and optionally from about 1% to about 50% (w/v) glycerin, wherein the concentration of nimodipine is about 6 mg/mL or greater or about 12 mg/mL, and wherein about 5% or less nimodipine degradation is observed over a period of at least six months when exposed to 40° C. and 75% relative humidity.
Dependencies are inferred from the claim text.