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AssigneeLeibniz-Institut Fur Alternsforschung—Fritz-Lipmann-Institut E.V. (Fli)
InventorsAlexander Schulz, Helen Morrison
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A polypeptide is provided that includes an EGF-like domain of a neuregulin protein. A nucleic acid encoding for the polypeptide is also provided. A gene therapy vector inclusive of the nucleic acid and genetically modified cells expressing said polypeptide are also provided. The medical use of the polypeptide, the nucleic acid, the gene therapy vector or the cell for the treatment of tumours of the nervous system are also provided. In particular the treatment of tumours of the cranial or peripheral nerves, tumours associated with neurofibromatosis, schwannomas, neurofibromas and malignant nerve sheath tumours are provided.
A method for treating and/or preventing a tumor of the nervous system in a subject, comprising administering a nucleic acid molecule to the subject, wherein the nucleic acid molecule encodes a polypeptide that comprises an EGF-like domain of a neuregulin protein.
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