Methods of promoting scfa production by gut microbiota
AssigneeMultigerm UK Enterprises Ltd.
InventorsBarry SMITH, Michael BUTLER
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Abstract
The invention relates to methods for promoting SCFA production by gut microbiota by administering a liquid, water-based probiotic composition. The methods are particularly effective at promoting gut health. The invention further relates to methods of promoting intestinal barrier integrity, methods of promoting a tolerogenic gut phenotype, and methods of treating Parkinson's Disease.
Claims37
A method of stimulating production of one or more short chain fatty acids (SCFAs) by a subject's gut microbiota comprising administering to the subject a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria.
A method of promoting gastrointestinal health in a subject comprising administering a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria, wherein administration of the probiotic preparation promotes production of one or more short chain fatty acids (SCFAs) by the subject's gut microbiota, thereby promoting intestinal health.
A method of promoting growth of one or more bacterial phyla selected from Actinobacteria (e.g. Bifidobacteriaceae), Firmicutes (e.g. Veillonellaceae, Lachnospiraceae, Streptococcaceae, Eubacteriaceae, Ruminococcaceae, Erysipelotrichaceae, Clostridiaceae), Proteobacteria (e.g. Enterobacteriaceae) in the gut microbiota of a subject, the method comprising administering to the subject a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria.
A method of inhibiting growth of one or more bacterial phyla selected from Actinobacteria (e.g. Coriobacteriaceae, Eggerthellaceae), Bacteroidetes (e.g. Bacteroidaceae, Rikenellaceae, Lachnospiraceae, Ruminococcaceae), Firmicutes (e.g., Acidaminococcaceae, Enterococcaceae, Clostridiaceae, Peptostreptococcaceae), Proteobacteria (e.g. Enterobacteriaceae), Synergistetes (e.g. Synergistaceae) and Verrucomicrobio (e.g. Akkermansiaceae) in the gut microbiota of a subject, the method comprising administering to the subject a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria
A method of promoting intestinal barrier integrity in a subject, the method comprising administering to the subject a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria, wherein administration of the probiotic preparation promotes said intestinal barrier integrity.
A method for promoting a tolerogenic gut phenotype in a subject, the method comprising administering to the subject a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria, wherein administration of the probiotic preparation promotes said tolerogenic gut phenotype.
A method according to any one of the preceding claims wherein the method is a non-therapeutic method.
A method according to any one of the preceding claims wherein the subject is a healthy individual.
A method according to any one of the preceding claims wherein the subject is in a state of intestinal dysbiosis.
A method of treating or preventing Parkinson's Disease in a subject, the method comprising administering to the subject a liquid, non-dairy probiotic preparation comprising a population of lactic acid bacteria.
A method according to any one of the preceding claims, wherein the method promotes production of one or more anti-inflammatory molecules by intestinal epithelial cells, optionally wherein the one or more anti-inflammatory molecules are selected from IL-6 and IL-10.
A method according to any one of the preceding claims, wherein the method reduces production of one or more pro-inflammatory molecules by intestinal epithelial cells, optionally wherein the one or more pro-inflammatory molecules are selected from CXCL-10, TNFa, IL-8 and MCP-1.
A method according to any one of the preceding claims wherein the population of lactic acid bacteria comprises one or more of Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus plantarum and Enterococcus faecium bacteria.
A method according to any one of the preceding claims wherein the population of lactic acid bacteria comprises each of Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus plantarum and Enterococcus faecium bacteria.
A method according to any one of the preceding claims wherein the method reduces production of one or more branched chain fatty acids (BCFA) and/or ammonium by the subject's gut microbiota
A method according to any one of the preceding claims wherein the probiotic composition is administered to the subject at least once a week, preferably once a day.
A method according to any one of the preceding claims wherein the probiotic composition is administered to the subject for a period of at least 1 month, at least 2 months or at least 3 months.
Dependencies are inferred from the claim text.