Lozenge
AssigneeMcNeil Corporation
InventorsKristina Thyresson, Katarina Lindell
Life of this patent
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Abstract
This invention relates to a nicotine lozenge giving an immediate release and uptake of nicotine and an extended release and uptake of nicotine as well as describing suitable manufacturing processes for such lozenge formulations and the use of the lozenge for the treatment of a human being suffering from cravings from tobacco and/or e-cigarette dependency.
Claims11
A lozenge comprising nicotine within a core, and
- i) a first portion/layer comprising at least one buffer and at least one sugar alcohol fused onto an outside of the core, and
- ii) a second portion/layer comprising a nicotine salt and at least one sugar alcohol fused onto the core,
- wherein a nicotine release from the second portion/layer is immediate and a nicotine release from the core is extended, and
- wherein the at least one buffer promotes a rapid uptake of nicotine through an oral mucosa.
The lozenge according to claim 10, wherein the at least one polymer-based film is selected from the group consisting of hydroxy propyl methyl cellulose (HPMC), methyl hydroxy ethyl cellulose (MHEC), hydroxy propyl cellulose (HPC), hydroxyethyl cellulose (HEC), ethyl hydroxyl ethyl cellulose (EHEC) and polyvinyl alcohol (PVOH or PVA).
A lozenge comprising nicotine within a core, and
- i) at least one polymer-based film coating covering the core comprising at least one buffer, at least one flavor and at least one sweetener, and
- ii) at least one portion/layer comprising a nicotine salt and at least one sugar alcohol fused onto the at least one polymer-based film coating,
- wherein a nicotine release from the at least one portion/layer is immediate and a nicotine release from the core is extended, and
- wherein the at least one buffer promotes a rapid uptake of nicotine through an oral mucosa.
A lozenge comprising nicotine within a core, and
- i) at least one polymer-based film coating covering the core comprising at least one flavor and at least one sweetener, and
- ii) a first portion/layer comprising at least one buffer and at least one sugar alcohol fused onto an outside of the at least one polymer-based film coating, and
- iii) a second portion/layer comprising a nicotine salt and at least one sugar alcohol fused onto an outside of the at least one polymer-based film coating,
- wherein a nicotine release from the second portion/layer is immediate and a nicotine release from the core is extended, and
- wherein the at least one buffer promotes a rapid uptake of nicotine through an oral mucosa.
Dependencies are inferred from the claim text.