Porous silicon nanoparticle-based drug delivery system inducing reactive oxygen species and self-activation thereof, and method for preparing same
AssigneeUniversity-Industry Cooperation Group of Kyung Hee University
InventorsDo Kyoung Kim, Rae Hyung Kang
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Abstract
Proposed is a porous silicon nanoparticle with isothiocyanate moiety conjugated to the surface. The porous silicon nanoparticle with isothiocyanate moiety conjugated to the surface has low side effects due to high biocompatibility, and can generate reactive oxygen species in cells without an external initiator, which can promote decomposition and release of supported drugs.
Claims11
A drug delivery system comprising:
- a porous silicon nanoparticles;
- and
- an isothiocyanate moiety conjugated to the surface of the porous silicon nanoparticle.
A pharmaceutical composition for treating cancer, the composition comprising a porous silicon nanoparticle and a drug delivery system comprising an isothiocyanate moiety conjugated to the surface of the porous silicon nanoparticle as an active ingredient.
A method for manufacturing a drug delivery system, the method comprising:
- preparing porous silicon nanoparticles;
- and
- conjugating an isothiocyanate moiety to the surface of the porous silicon nanoparticle.
Dependencies are inferred from the claim text.