Treatment of liver injury
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
InventorsAlexander K. Shalek, Kellie Elizabeth Kolb, Chad Walesky, Wolfram Goessling
Life of this patent
Estimating the term…
Abstract
A method of treating an injury in an organ or tissue includes administering to a subject in need thereof an agent that modulates expression and/or activity of one or more genes involved in the regeneration and functional compensation of the tissue or organ in response to the injury.
Claims32
A method of treating liver injury comprising
- stimulating functional compensation in liver cells by administering an agent that stimulates macrophage Wnt signaling.
A method of decreasing cancer susceptibility and/or inflammation comprising administering a subject in need thereof an inhibitor of peroxisome proliferator-activated receptors (PPARs).
A method of reducing risk of proliferation disorders or cancer in the liver comprising administering to a subject in need thereof an agent that increases expression of Sox9 or decreases expression of Lrg5 and Axin 2.
A method of treating an injury in an organ or tissue, comprising:
- administering to a subject in need thereof an agent that modulates expression and/or activity of one or more genes or gene products that have functions in:
- regulation of proteolysis, chemical homeostasis, secretion by cells, regulation of hydrolase activity, regulation of body fluid levels, homeostatic process, wound healing, glycerolipid metabolic process, response to external stimuli, response to oxygen containing compounds, response to lipid, neutral lipid metabolic process, negative regulation of hydrolase activity, ion homeostasis, response to biotic stimulus, exocytosis, platelet degranulation, response to alcohol, regulated exocytosis, negative regulation of peptidase activity, extracellular matrix, secretory granule, platelet alpha granule, secretory granule lumen, secretory vesicle, vesicle lumen, blood microparticle, intracellular vesicle, extracellular space, cytoplasmic vesicle part, protein lipid complex, enzyme inhibitor activity, enzyme regulator activity, response to hypoxia, apoptosis, complement components functions and activities, or a combination thereof.
A method of treating an injury in an organ or tissue, comprising:
- a. determining expression of one or more genes from single cells in the organ or tissue at a first time point and a second time point;
- b. selecting a first subset of genes from the one or more genes, wherein expression of the first subset of genes at the first and the second time points are different;
- c. determining spatial locations of cells expressing the first subset of genes in the organ or tissue at the first and the second time points by an in situ hybridization assay;
- d. selecting a second subset of genes based on the spatial locations of the cells expressing the second subset of genes;
- and
- e. administering an agent that modulates expression and/or activity of one or more of the second subset of genes to a subject in need thereof.
Dependencies are inferred from the claim text.