Antimicrobial peptides
AssigneeMATERIAS S.r.l.
InventorsMarco Balestrieri, Gianna Palmieri, Gianluca Neglia, Aniello Anastasio, Federico Capuano, Luca De Stefano, Luigi Nicolais
Life of this patent
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Abstract
The present invention relates to the use of at least one peptide having sequence VRLIVAVRIWRR, VRLIVAVRIKRR, VRLIVKVRIWRR, VRLIVKVRIKRR (SEQ ID NO: 1, SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4), as a bactericidal antimicrobial agent against Listeria monocytogenes.
Claims19
A method for the prevention and/or treatment of contamination of a product or a surface by Listeria monocytogenes, the method comprising contacting the product or surface with a mixture of at least two peptides selected from the group consisting of VRLIVAVRIWRR (SEQ ID NO:
- 1), VRLIVAVRIKRR (SEQ ID NO:
- 2), VRLIVKVRIWRR (SEQ ID NO:
- 3), and VRLIVKVRIKRR (SEQ ID NO:
- 4), or a salt or solvate thereof.
A method for the treatment of an infection from Listeria monocytogenes in a subject in need thereof, said method comprising administering a mixture of at least two peptides, wherein the peptides have the amino acid sequence selected from the group consisting of VRLIVAVRIWRR (SEQ ID NO:
- 1), VRLIVAVRIKRR (SEQ ID NO:
- 2), VRLIVKVRIWRR (SEQ ID NO:
- 3), and VRLIVKVRIKRR (SEQ ID NO:
- 4), or a pharmaceutically acceptable salt or solvate thereof.
Antimicrobial composition or pharmaceutical composition comprising a mixture of at least one peptide selected from the group consisting of VRLIVAVRIWRR (SEQ ID NO:
- 1) and VRLIVAVRIKRR (SEQ ID NO:
- 2) and at least one peptide selected from the group consisting of VRLIVKVRIWRR (SEQ ID NO:
- 3) and VRLIVKVRIKRR (SEQ ID NO:
- 4).
Product having at least one surface linked to at least two peptides selected from the group consisting of VRLIVAVRIWRR (SEQ ID NO:
- 1), VRLIVAVRIKRR (SEQ ID NO:
- 2), VRLIVKVRIWRR (SEQ ID NO:
- 3), and VRLIVKVRIKRR (SEQ ID NO:
- 4), or a salt or solvate thereof, wherein said at least two peptides are linked to said surface by means of a covalent bond between N-terminal amino group of the peptide and a chemical group on said surface.
Nanoparticles comprising, covalently linked to their surface, at least two peptides selected from the group consisting of VRLIVAVRIWRR (SEQ ID NO:
- 1), VRLIVAVRIKRR (SEQ ID NO:
- 2), VRLIVKVRIWRR (SEQ ID NO:
- 3), and VRLIVKVRIKRR (SEQ ID NO:
- 4).
Dependencies are inferred from the claim text.