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US 2023/0053458 A1Published application
Methods for providing continuous therapy against pnag comprising microbes
AssigneeAlopexx Inc.
InventorsMichael WYAND, Gerald F. SWISS
Life of this patent
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Abstract
Disclosed are antimicrobial vaccines comprising oligosaccharide β-(1→6)-glucosamine groups.
Claims18
A method of providing continuous protection against microbial infection, which method comprises administering to said patient a therapeutically effective amount of a monoclonal antibody F-598 and a vaccine of formula I:
- (A−B)x−C I
- wherein A comprises 3 to 12 β-(1→6)-glucosamine (carbohydrate ligand) groups or mixtures thereof wherein said oligosaccharide portion of the vaccine is represented by formula A:
- B is a linker;
- where A is as defined above and C is tetatus toxoid;
- x is an integer from about 30 to about 39;
- and
- y is an integer from 1 to 10.
4 more elements
A method of inhibiting biofilm formation comprising administering to a patient a therapeutically effective amount of a monoclonal antibody F-598 and a vaccine of formula I:
- (A−B)x−C I
- wherein A comprises 3 to 12 β-(1→6)-glucosamine (carbohydrate ligand) groups or mixtures thereof wherein said oligosaccharide portion of the vaccine is represented by formula A:
- B is a linker;
- where A is as defined above and C is tetatus toxoid;
- x is an integer from about 30 to about 39;
- and
- y is an integer from 1 to 10.
4 more elements
Dependencies are inferred from the claim text.