Imidazolidinone compound, preparation method therefor and use thereof

A compound of Formula (I) or a stereoisomer, geometric isomer or tautomer, or a pharmaceutically acceptable salt, solvate, chelate, non-covalent complex or prodrug thereof,

• wherein,
• X is selected from O and S;
• R1 is selected from H, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl, C5-8 heteroaryl, ORa and —NRaRb;
• wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl and C5-8 heteroaryl are each optionally substituted with one or more substituents selected from halogen, CN, ORa, oxo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl and C3-6 heterocyclyl;
• R2 is selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl, C5-8 heteroaryl;
• wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl and C5-8 heteroaryl are each optionally substituted with one or more substituents selected from halogen, CN, —OH, —NO2, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl, C2-6 haloalkynyl, C3-6 cycloalkyl, C3-6 halocycloalkyl, C3-6 heterocyclyl, C3-6 haloheterocyclyl, C6-8 aryl, C6-8 haloaryl, C5-8 heteroaryl, C5-8 haloheteroaryl, oxo, —ORa, —NRaRb, —C(O)Ra, —C(O)O Ra, —C(O)NRaRb, —S(O)Ra and —S(O)2Ra;
• R3 is selected from H, halogen, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —ORa and —NRaRb;
• wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl are each optionally substituted with one or more substituents selected from halogen, CN, —ORa, —NRaRb, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —S(O)Ra and —S(O)2Ra;
• R4 is selected from H, halogen, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, C1-6 haloalkyl, C2-6 haloalkenyl, C2-6 haloalkynyl, C1-6 alkoxy, C1-6 halo alkoxy, —ORa, —NRaRb, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —S(O)Ra and —S(O)2Ra;
• R5 is selected from H, halogen, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C2-6 haloalkenyl, C2-6 haloalkynyl, C1-6 alkoxy, C1-6 haloalkoxy, —ORa, —NRaRb, —S(O)Ra and —S(O)2Ra;
• R6 is selected from H, halogen, CN, oxo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl, C5-8 heteroaryl, —ORa, —NRaRb, —C(O)Ra, —C(O)O Ra, —C(O) NRaRb, —S(O)Ra and —S(O)2Ra;
• wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl and C5-8 heteroaryl are each optionally substituted with one or more substituents selected from halogen, CN, oxo, —NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —ORa, —NRaRb, —C(O)Ra, —C(O)O Ra, —C(O)NRaRb, —S(O)Ra and —S(O)2Ra;
• or,
• two R6 take with the C atoms which they are attached to form C3-6 cycloalkyl or C3-6 heterocyclyl;
• Ra and Rb are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl, C5-8 heteroaryl;
• wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-6 cycloalkyl, C3-6 heterocyclyl, C6-8 aryl, C5-8 heteroaryl are optionally substituted with halogen, CN, —OH, —NH2, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy;
• m is selected from 0, 1, 2, 3 and 4;
• n is selected from 0, 1, 2 and 3;
• and
• y is selected from 0, 1, 2, 3, 4, 5 and 6.