2-beta-naphthyl-acetic acid analogs as akr1c3 inhibitors and methods of using same

A compound of formula (I), or a salt, solvate, or stereoisomer thereof:

• wherein:
• R1 is selected from the group consisting of OH, —NHSO2(C1-C6 alkyl), C1-C6 alkoxy, and C3-C8 cycloalkoxy, wherein the alkyl, alkoxy or cycloalkoxy group is optionally substituted with at least one substituent selected from C1-C6 alkyl, C3-C8 cycloalkyl, optionally substituted aryl, OH, C1-C6 alkoxy, halogen, and —CN;
• R2 and R3 are independently selected from the group consisting of H, C1-C6 alkyl, and C3-C8 cycloalkyl, wherein the alkyl or cycloalkyl is optionally substituted with at least one selected from the group consisting of C1-C6 alkyl and C3-C8 cycloalkyl;
• R4 is selected from the group consisting of C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C3-C8 cycloalkoxy, —S(C1-C6 alkyl), —S(C3-C8 cycloalkyl), —S(═O)(C1-C6 alkyl), —S(═O)(C3-C8 cycloalkyl), —S(═O)2(C1-C6 alkyl), and —S(═O)2(C3-C8 cycloalkyl);
• wherein the compound is not a compound wherein R1 is OH, one of R2 and R3 is methyl and the other is H, and R4 is methoxy.