Centrifuge tube, centrifuge adapter, device for the production of a prp-containing medicamente and single-use kit for manual production of prp
AssigneePrometheus, Inc.
InventorsRiccardo DELLA RAGIONE, Alice MICHELANGELI, Valentina MENOZZI
Life of this patent
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Abstract
A separation container, an adapter device for centrifuge stations of bench centrifuges, and a production device of a medication comprising platelet-rich plasma are disclosed. Also disclosed are a manual production method of platelet-rich plasma and a manual production method of a medication actuable using the container and the devices.
Claims10
A separation container, which is sterilisable and comprising:
- a test tube for a bench centrifuge, the test tube having a relative conical bottom portion, a first opening which is opposite the conical bottom portion, wherein the test tube internally defines a relative first housing;
- a cap which is engageable with the first opening of the test tube, the cap having:
- a first, a second and a third hole which are through-holes;
- a first and a second needle free connector respectively engaged, in the first and in the second hole in order to close them, wherein, when the cap is engaged with the first opening, each of the first and second needle free connectors is arranged in such a way that a relative compression valve is arranged distally to the test tube;
- a filter engaged in the third hole and having pores of dimensions that are equal to or smaller than 0.4 μm in order to allow only passage of microbiologically filtered air in conjunction with the transfer of a liquid through the first and/or the second needle free connector when the relative compression valve is compressed;
- a tube which originates from the cap at the first needle free connector so that, when the cap is engaged with the first opening, the tube is arranged internally of the first housing with a relative terminal portion having a relative terminal end, arranged distally of the cap and at the conical bottom portion of the test tube, and wherein said terminal portion of the tube is tapered towards the relative terminal in order to obtain a Venturi effect when a liquid is introduced into the test tube, through the first needle free connector and the tube, to enable re-mixing of a sediment of particles and of a supernatant liquid when contained in the separation container.
An adapter device for centrifuge stations of bench centrifuges comprising:
- a tubular wall which is externally cylindrical;
- the adapter device has a relative axis that is longitudinal and internally defines a second housing, which is accessible from a first end of the tubular wall;
- the second housing having a relative maximum length that is greater than or equal to a relative maximum width, measured along a transversal plane to the axis, wherein the tubular wall has, at a relative first and a relative second longitudinal sector, opposite one another with respect to the axis, a first thickness that is uniform and wherein, at a relative third and a relative fourth longitudinal sector, which are opposite one another with respect to the axis, the longitudinal wall has a relative thickness that is not uniform and that is smaller than the first thickness, and a base wall which closes the second housing at a second longitudinal end of the tubular wall;
- the adapter device being insertable in the relative second longitudinal end, in a cylindrical station of a bench centrifuge for, when inserted, enabling housing, in the second housing, between the first and second longitudinal sector, a test tube for centrifuges having a smaller diameter than the maximum width and having dimensions such that, during the centrifugation, the test tube remains between the first and second longitudinal sector, or enabling housing, in the second housing, a medical bag for collecting liquids, having dimensions such that, when at least partially filled, and once housed, it extends from the third and fourth longitudinal sector.
A production device of a medication comprising platelet-rich plasma, the device being sterile and comprising:
- a first medical bag for collection of biological liquids having a relative first wall and a relative second wall, opposite one another and defining a relative third internal housing, which is accessible from a second opening of the first medical bag,
- a third needle free connector arranged in and engaged with the second opening, in such a way that a relative compression valve is arranged distally to the third housing;
- a support element which comprises:
- a first support layer made of a bio-resorbable material, preferably porous;
- a second layer, made of a second bio-resorbable material, arranged on the first layer, wherein the second bio-resorbable material is a polymeric sponge or is a substance selected from a group constituted by:
- sodium alginate, gelatin, collagen and/or chitosan and combinations thereof and wherein the medical support is contained in the third housing and is arranged with the first layer in contact with the first wall and with the second layer in contact with the second internal wall.
Dependencies are inferred from the claim text.