Influenza virus mutants and uses therefor
AssigneeFluGen, Inc.
InventorsPamuk BILSEL, Yasuko HATTA
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Abstract
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
Claims14
-55. (canceled)
A method for immunizing a subject, comprising:
- administering a composition comprising a recombinant influenza virus comprising mutation in the M gene, wherein the mutation in the M gene results in failure of the virus to express the M2 protein, or causes the virus to express a truncated M2 protein having the amino acid sequence of SEQ ID NO:4.
A method for reducing the likelihood or severity of infection by influenza A virus in a subject comprising:
- administering a composition comprising a recombinant influenza virus comprising mutation in the M gene, wherein the mutation in the M gene results in failure of the virus to express the M2 protein, or causes the virus to express a truncated M2 protein having the amino acid sequence of SEQ ID NO:4.
A method for intracutaneous administration of an immunogenic composition comprising:
- (a) providing a microneedle delivery device comprising (i) a puncture mechanism;
- (ii) an immunogenic composition layer comprising a plurality of microneedles capable of puncturing skin and allowing an immunogenic composition to be administered intracutaneously;
- and
- (b) depressing the puncture mechanism;
- wherein the immunogenic composition comprises a recombinant influenza virus comprising a mutation in the M gene, and wherein the mutation in the M gene results in failure of the virus to express the M2 protein, or causes the virus to express a truncated M2 protein having the amino acid sequence of SEQ ID NO:4.
Dependencies are inferred from the claim text.