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US 2022/0387458 A1Published application
Methods of manufacturing microspheres
AssigneeApplaud Medical, Inc.
InventorsDaniel J. Laser, Alice Luong, Robert G. Miotke
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Abstract
The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.
Claims20
A method of manufacturing microspheres, the method comprising:
- (a) preparing a formulation for making microspheres comprising at least one of:
- i. a compound of Formula I
- or a salt, isomer, or salt of an isomer thereof;
- ii. a compound of Formula II
- or a salt, isomer, or salt of an isomer thereof;
- and
- iii. a compound of Formula III
- or a salt, isomer, or salt of an isomer thereof;
- wherein:
- n is from 10 to 30,
- m is from 1 to 100,
- t is from 10 to 30,
- y is from 1 to 100,
- z is from 10 to 30, and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH, SO3H and PO3H;
- and
- optionally further comprising at least one pharmaceutically acceptable excipient and/or water.
15 more elements
A method of reconstituting microspheres, wherein the method comprises the steps of:
- (a) obtaining a unit dosage vessel comprising a pharmaceutical composition comprising a therapeutically effective amount of a microsphere composition and optionally, at least one pharmaceutically acceptable excipient;
- wherein the microsphere composition comprises at least one of:
- i. a compound of Formula I
- or a salt, isomer, or salt of an isomer thereof;
- ii. a compound of Formula II
- or a salt, isomer, or salt of an isomer thereof;
- and
- iii. a compound of Formula III
- or a salt, isomer, or salt of an isomer thereof;
- wherein:
- n is from 10 to 30;
- m is from 1 to 100;
- tis from 10 to 30;
- y is from 1 to 100;
- z is from 10 to 30;
- and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH, SO3H and PO3H;
- (b) adding a sufficient amount of water or a saline solution to the vessel,
- (c) optionally, adding a volume of a fluid having a normal boiling point of less than 30° C. to the vessel of step (a);
- and
- (d) optionally shaking the container of step (a) or step (b);
- wherein the shaking of the container optionally lasts no more than 180 seconds.
20 more elements
Dependencies are inferred from the claim text.