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US 2022/0380360 A1Published application
Benzoselenophene-based compound, pharmaceutical composition containing same, and antibody-drug conjugate
AssigneeAimed Bio Inc.
InventorsDongyeol LIM, Min Cheol KIM, Amol MHETRE, Do-Hyun NAM
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Abstract
The present disclosure relates to a benzoselenophene-based compound, a method of preparing the benzoselenophene-based compound, and a pharmaceutical composition and antibody-drug conjugate including the benzoselenophene-based compound.
Claims21
A benzoselenophene-based compound, represented by the following Chemical Formula 1:
- in the above Chemical Formula 1,
- R1 is a substituted or unsubstituted C3-10 heterocycloalkyl group, a substituted or unsubstituted C5-10 aryl group, or a substituted or unsubstituted C3-10 heteroaryl group,
- each of R2 and R3 is independently hydrogen, fluorine, chlorine, bromine, iodine, or a substituted or unsubstituted C1-5 alkyl group,
- each of R4 and R5 is independently hydrogen, or a substituted or unsubstituted C1-5 alkyl group,
- the heterocycloalkyl group and the heteroaryl group include at least one hetero atom selected from N, O and S, and
- X is halogen.
3 more elements
A pharmaceutical composition, comprising a benzoselenophene-based compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof,
- the pharmaceutical composition is for preventing or treating proliferative diseases:
- in the above Chemical Formula 1,
- R1 is a substituted or unsubstituted C3-10 heterocycloalkyl group, a substituted or unsubstituted C5-10 aryl group, or a substituted or unsubstituted C3-10 heteroaryl group,
- each of R2 and R3 is independently hydrogen, fluorine, chlorine, bromine, iodine, or a substituted or unsubstituted C1-5 alkyl group,
- each of R4 and R5 is independently hydrogen, or a substituted or unsubstituted C1-5 alkyl group,
- the heterocycloalkyl group and the heteroaryl group include at least one hetero atom selected from N, O and S, and
- X is halogen.
4 more elements
an antibody-drug conjugate or a pharmaceutically acceptable salt thereof, comprising:
- an antibody;
- a linker;
- and
- a benzoselenophene-based compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof:
- in the above Chemical Formula 1,
- R1 is a substituted or unsubstituted C3-10 heterocycloalkyl group, a substituted or unsubstituted C5-10 aryl group, or a substituted or unsubstituted C3-10 heteroaryl group,
- each of R2 and R3 is independently hydrogen, fluorine, chlorine, bromine, iodine, or a substituted or unsubstituted C1-5 alkyl group,
- each of R4 and R5 is independently hydrogen, or a substituted or unsubstituted C1-5 alkyl group,
- the heterocycloalkyl group and the heteroaryl group include at least one hetero atom selected from N, O and S, and
- X is halogen.
7 more elements
Dependencies are inferred from the claim text.