Composition for removing pluripotent stem cells and method of removing pluripotent stem cells
AssigneeNational University Corporation Hokkaido University
InventorToru KONDO
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Abstract
An object is to provide a composition and a method for eliminating undifferentiated pluripotent stem cells remaining in a cell group induced to differentiate from pluripotent stem cells. It has been found that while dihydroorotate dehydrogenase inhibitors exhibit cytotoxic activity against pluripotent stem cells, they do not exhibit significant cytotoxic activity against differentiated cells such as somatic stem cells.
Claims8
A composition for eliminating undifferentiated pluripotent stem cells remaining in a cell group induced to differentiate from pluripotent stem cells, comprising:
- a dihydroorotate dehydrogenase inhibitor as an active ingredient.
A method for eliminating undifferentiated pluripotent stem cells remaining in a cell group, comprising:
- contacting a cell group induced to differentiate from pluripotent stem cells with a dihydroorotate dehydrogenase inhibitor.
Dependencies are inferred from the claim text.