Assembly for extracorporeal treatment of body fluids

A method for extracorporeal treatment of a body fluid of a patient suffering from a dysregulated immune response, in an extracorporeal flow line, comprising removing at least one harmful substance from the body fluid of the patient, comprising the following steps:

• at least a first injection step, in which, by means of a first injection device, a first mixture containing functionalized magnetic particles bound to at least a first binding agent at least directed against a first type of target molecules contained in the body fluid is added to the extracorporeal flow line comprising a sample of the body fluid extracted from a patient suffering from a dysregulated immune response, e.g. sepsis, and containing at least the first type of target molecules, in a therapeutically effective dose necessary to reduce a concentration of the target molecules of at least the first type in the sample of body fluid of the patient,
• subsequently, mixing the body fluid comprising the functionalized magnetic particles to ensure sufficient binding of the target molecules of at least the first type to the functionalized magnetic particles;
• and
• separating the functionalized magnetic particles bound to the target molecules of at least the first type from the sample of body fluid, such that a concentration of target molecules of at least the first type in the sample of body fluid is reduced,
• wherein the first injection step is controlled based on data obtained from the sample of the patient's body fluid providing information about the immunological status of the patient, and
• wherein the first injection step is controlled in terms of at least one of the following:
• injection rate, time of injection, injection dose, concentration, injection pressure.