Pharmaceutical compositions, kits and methods for treating tumors
AssigneeImmvira Co., Limited
InventorsXiaoqing Chen, Xusha Zhou, Bernard Roizman, Grace Guoying Zhou
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Abstract
Provided is a composition for treating tumors in a subject comprising a therapeutically effective amount of an exosome carrying CTLA4-targeting miRNA and a therapeutically effective amount of an oncolytic herpes simplex virus expressing an immunostimulatory agent or both an immunostimulatory agent and an anti-PD-1 antibody. Wherein an exo-motif operably links to the seed sequence of the CTLA4-targeting miRNA to enhance the packaging of the CTLA4-targeting miRNA into the exosome.
Claims23
A pharmaceutical composition or a kit for treating a tumor in a subject, comprising,
- (a) a therapeutically effective amount of an exosome,
- (b) a therapeutically effective amount of an oncolytic herpes simplex virus, and
- (c1) a pharmaceutically acceptable carrier, for the pharmaceutical composition, or (c2) optionally instructions for use, for the kit,
- wherein the exosome comprises an inhibitory amount of CTLA-4-targeting miRNA and an exo-motif operably linked to a seed sequence of the CTLA-4-targeting miRNA to enhance the packaging of the CTLA-4-targeting miRNA into the exosome, and
- wherein the oncolytic herpes simplex virus expresses an immunostimulatory agent or both an immunostimulatory agent and an anti-PD-1 antibody.
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22-42. (canceled)
Dependencies are inferred from the claim text.