Cell culture media containing combinations of proteins
AssigneeVentria Bioscience
InventorsSteven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
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Abstract
The present invention relates to cell culture media supplements or complete media compositions comprising plant-produced heterologous recombinant human albumin, as well as methods of making the cell culture media, and methods of using the supplemented cell culture media to improve viability, productivity, and growth characteristics of cultured cells.
Claims30
A cell culture media supplement or complete media composition for improving growth, viability, and/or productivity of cultured cells as compared to cells grown without said supplement or complete media composition, said cell culture media supplement or complete media composition comprising a plant-produced heterologous protein, wherein said plant-produced heterologous protein is recombinant human albumin, said recombinant human albumin comprising:
- i) less than about 1 EU of endotoxin/mg of albumin;
- and
- ii) less than about 10 ppm detergent.
A cell culture media supplement or complete media composition for improving growth, viability, and/or productivity of cultured cells as compared to cells grown without said supplement or complete media composition, said cell culture media supplement or complete media composition comprising a plant-produced heterologous protein, wherein said plant-produced heterologous protein is recombinant human albumin, said recombinant human albumin comprising:
- i) less than about 1 EU of endotoxin/mg of albumin;
- and
- ii) a monocot seed component, wherein said monocot seed component is a plant carbohydrate or plant lipid.
Dependencies are inferred from the claim text.