Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application

An aromatic vinyl or aromatic ethyl derivative represented by general formula (I), or a pharmaceutically acceptable salt thereof:

• wherein,
• is a single bond or a double bond;
• each of R1 is identical or different, and is independently deuterium, halogen, substituted or unsubstituted hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted alkyl, or substituted or unsubstituted alkoxy;
• or two adjacent R1 together with the two carbon atoms to which they are attached form a 5- to 7-membered carbocyclic ring or heterocarbocyclic ring;
• in the heterocarbocyclic ring, the heteroatom(s) is(are) oxygen and/or nitrogen, and the number of the heteroatom(s) is 1 to 4;
• R2 is substituted or unsubstituted alkyl or halogen;
• each of R3 is identical or different, and is independently deuterium, halogen, substituted or unsubstituted alkylthio, substituted or unsubstituted hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy,
• wherein R1a is C1-C4 alkyl, or two adjacent R3 together with the two carbon atoms to which they are attached form a 5- to 7-membered carbocyclic ring or heterocarbocyclic ring;
• in the heterocarbocyclic ring, the heteroatom(s) is(are) oxygen and/or nitrogen, and the number of the heteroatom(s) is 1 to 4;
• when two R3 are adjacent, and the two adjacent R3 together with the two carbon atoms to which they are attached form a 5- to 7-membered carbocyclic ring or heterocarbocyclic ring, then the carbocyclic ring or heterocarbocyclic ring is further substituted by one or more than one C1-C4 alkyl;
• the substituent(s) in the substituted alkyl in each of R1, R2 and each of R3, the substituent(s) in the substituted alkoxy in each of R1 and each of R3, and the substituent(s) in the substituted alkylthio in each of R3 are one or more selected from halogen, C1-4 alkyl, hydroxyl,
• C1-4 alkoxy, C1-4 carboxyl, C1-4 ester group and C1-4 amide group;
• when there are more substituents than one, then the substituents are identical or different;
• Ra and Rb are independently hydrogen, or, substituted or unsubstituted alkyl;
• in Ra or Rb, the substituent(s) in the substituted alkyl is(are) one or more selected from halogen, C1-C4 alkyl, hydroxyl,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group and C1-C4 amide group;
• Ra1 and Rb1 are independently hydrogen or C1-C4 alkyl;
• in each of R1 or R3, the substituent(s) in the substituted hydroxyl or the substituted amino is(are) one or more selected from C1-4 alkyl, C1-4 alkoxy, C1-4 carboxyl, C1-4 ester group and C1-4 amide group;
• m is 1, 2 or 3;
• n is 0, 1, 2 or 3;
• when is a double bond and in is 2, then two R1 are located on ortho and meta positions of the phenyl, and the two R1 are identical or different;
• when is a double bond and m is 3, then two of R1 are adjacent, and the two adjacent R1 together with the two carbon atoms to which they are attached form a 5- to 7-membered heterocarbocyclic ring;
• or in the aromatic vinyl or aromatic ethyl derivative represented by general formula (I),
• is replaced by a substituted or unsubstituted heteroaromatic ring, in the heteroaromatic ring, the heteroatom(s) is(are) selected from nitrogen, oxygen and sulfur, and the number of the heteroatom(s) is 1 to 4;
• the substituent(s) in the substituted heteroaromatic ring is(are) one or more selected from halogen, C1-4 alkyl, hydroxyl,
• C1-4 alkoxy, C1-4 carboxyl, C1-4 ester group and C1-4 amide group;
• when there are more substituents than one, then the substituents are identical or different;
• Ra and Rb are independently hydrogen, or, substituted or unsubstituted alkyl;
• in Ra or Rb, the substituent(s) in the substituted alkyl is(are) one or more selected from halogen, C1-C4 alkyl, hydroxyl,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group and C1-C4 amide group;
• Ra1 and Rb1 are independently hydrogen or C1-C4 alkyl;
• the aromatic vinyl or aromatic ethyl derivative represented by general formula (I) excludes the compound: