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AssigneesVir Biotechnology, Inc., Triad National Security, LLC
InventorsEric BRUENING, Janet DOUGLAS, Emily MARSHALL, Karina YUSIM, Bette KORBER, James THEILER
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The present disclosure relates to isolated polynucleotides and polypeptides, and related hepatitis B virus (HBV)vaccines. The present disclosure also relates to viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines described herein. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area are also provided herein.
A polypeptide comprising the amino acid sequence as set forth in SEQ ID NOs:1-11 or SEQ ID NOs:14-36.
A polypeptide comprising two or more amino acid sequences as set forth in SEQ ID NOs:16-36.
A cytomegalovirus (CMV) vector comprising a polynucleotide comprising the sequence encoding one or more amino acid sequences as set forth in SEQ ID NOs:1-36.
A hepatitis B virus (HBV) vaccine comprising a CMV vector and a polynucleotide encoding one or more HBV episensus antigens.
An HBV vaccine comprising:
A method of designing and producing an HBV vaccine for a subject in a geographic area comprising:
A method of designing and producing an HBV vaccine for a subject comprising:
A method of inducing an effector memory T cell response comprising:
A method of treating an HBV infection in a subject comprising:
A method of preventing an HBV infection in a subject comprising:
A method of inducing an immune response to HBV in a subject comprising:
A method of inducing an effector memory T cell response in a subject comprising:
Dependencies are inferred from the claim text.