Libraries for identification of genomic variants
AssigneeTwist Bioscience Corporation
InventorsLeonardo ARBIZA, Siyuan CHEN, Ramsey Ibrahim ZEITOUN
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Abstract
Provided herein are compositions and methods for identifying genomic variants. Further provided herein are compositions and methods for capture of genomic sequences. Further provided herein are compositions and methods for capturing genomic DNA comprising single nucleotide polymorphisms.
Claims31
A polynucleotide library comprising at least 1000 polynucleotides, wherein at least some of the 1000 polynucleotides are configured to hybridize to genomic fragments of a genome, wherein at least some of the 1000 polynucleotides are configured to bind to regions of the genome comprising at least two genomic variants, and wherein the at least 1000 polynucleotides of the polynucleotide library are configured to bind to about three genomic variants per polynucleotide.
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A method for generating a polynucleotide library comprising:
- a. providing a target region, wherein the region comprises at least two genomic variants;
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- b. generating a polynucleotide library, wherein the polynucleotide library collectively is configured to bind to the target region, and wherein at least some of the polynucleotides in the library are configured to bind to a portion of the target region, wherein the portion of the target region comprises at least two genomic variants.
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Dependencies are inferred from the claim text.