Antibodies specific to glycosylated pd-l1 and methods of use thereof
AssigneesStcube, Inc., Board of Regents, The University of Texas
InventorsStephen S. YOO, Ezra M. CHUNG, Yong-Soo KIM, Mien-Chie HUNG, Chia-Wei LI, Seung-Oe LIM
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Abstract
Antibodies that selectively bind to glycosylated PD-1 relative to unglycosylated PD-1 are provided. In some aspects, PD-1 polypeptides comprising glycosylated amino acid positions are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.
Claims33
An isolated chimeric, humanized, or fully human monoclonal antibody which selectively binds to glycosylated PD-1 relative to unglycosylated PD-1.
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