US 2022/0257624 A1 · COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASE

Abstract

The invention described herein relates to oral dosage form therapies for treating metabolic disorders using combinations of inhibitors of SGLT1 and SGLT2. In such dosage forms, SGLT1 is effective in the intestinal lumen, and is either not absorbed, or poorly absorbed, while the SGLT2 inhibitor inhibits sugar reabsorption in the kidney by inhibiting SGLT2 activity. Metabolic disorders treated by combined SGLT1 and SGLT2 oral dosage forms include disorders associated with abnormal accumulation of liver lipids, which may also be copresent with hyperglycemia. Combinations of SGLT1 and SGLT2 inhibitors are contemplated herein, particularly combinations

Claims18

Dependent claims

An oral dosage form comprising:

A) a SGLT2 inhibitor compound or pharmaceutically acceptable salt thereof;
and
B) a SGLT1 inhibitor compound or pharmaceutically acceptable salt thereof;
wherein the SGLT2 inhibitor compound or pharmaceutically acceptable salt thereof is absorbed systemically and the SGLT1 inhibitor compound or pharmaceutically acceptable salt thereof is not absorbed systemically or poorly absorbed systemically from the intestinal lumen of a subject that ingests the oral dosage form.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

17/614,055Filed 1 Jun 2020

Priority

31 May 2019

Published

18 Aug 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 31/706
Having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides: containing six-membered rings with nitrogen as a ring hetero atom
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 31/351
Having six-membered rings with one oxygen as the only ring hetero atom: not condensed with another ring
A61K 31/70
Medicinal preparations containing organic active ingredients: carbohydrates; Sugars; Derivatives thereof

Compositions and methods for treating metabolic disease

Life of this patent

Compositions and methods for treating metabolic disease

Life of this patent

Abstract

Claims18