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US 2022/0234990 A1Published application
Methods of synthesis of (1r,2r,5r)-5-amino-2-methyl-cyclohexanol hydrochloride and intermediates useful therein
AssigneeCelgene Corporation
InventorsTerrence Joseph CONNOLLY, Hon-Wah MAN, Periyandi NAGARAJAN, Chinnapillai RAJENDIRAN, Jasti VENKATESWARLU
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Abstract
Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.
Claims14
1-22. (canceled)
A method for preparing a compound of formula (9):
- the methods comprising contacting a compound of formula (8):
- with a mixture of a reducing agent, a chiral auxiliary and a Lewis acid in a solvent, followed by treatment with an oxidant in the presence of a base.
Dependencies are inferred from the claim text.