Back to results
US 2022/0234987 A1Published application
Styryl carboxylate derivatives
AssigneeRenovel Innovations, Inc.
InventorsBishwajit Nag, Ananda Sen, Nitish Nag, Arjun Sanyal, Srinivasan Narasimhan
Life of this patent
Estimating the term…
Abstract
Novel Styryl Carboxylate derivatives are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases, and diabetes.
Claims19
A compound of Formula (I)
- or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 is selected from a group consisting of hydrogen, phenoxy, amino, sulphonyl, substituted or unsubstituted straight chain or branched alkyls derivatives and halogens;
- wherein each of R6 and R8 on ring B is selected from the group consisting of hydrogen, hydroxy, alkoxy and branched or unbranched alkyl derivatives;
- wherein R7 is selected from a group consisting of (i) a carbonyl group through which free amino group containing molecules can form condensates, (ii) an ethanedithiol group and (iii) a propanedithiol group;
- and wherein each of X and Y on ring B is a halogen.
1 more element
A method for the preparation of the styryl carboxylate compounds of formula (I),
- or of the analog, tautomeric form, stereoisomer, polymorph, or pharmaceutically acceptable salt thereof,
- wherein R1, R2, R3, R4 and R5 are predominantly hydrogens,
- wherein R7 is selected from a group consisting of (i) a carbonyl group through which free amino group containing molecules can form condensates, (ii) an ethanedithiol group and (iii) a propanedithiol group,
- wherein each of R6 and R8 on ring B is selected from the group consisting of hydrogen, hydroxy, alkoxy and branched or unbranched alkyl derivatives,
- and wherein each of X and Y on ring B is a halogen;
- said method comprising the steps as shown in Scheme (I):
- wherein the step from (4) to (4a) is optional depending on the required product.
4 more elements
Dependencies are inferred from the claim text.