Novel d3 dopamine receptor agonists to treat dyskinesia in parkinson's disease

A method of treating, ameliorating or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, the method comprising administering to the patient a therapeutically effective amount of at least one compound selected from the group consisting of:

• a compound of formula (I):
• wherein in formula (I):
• R1, R2 and R3 are independently selected from the group consisting of H, cyano, hydroxyl, amino, acetamido, halo, alkoxy, nitro, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, substituted aryl-(C1-3)alkyl, carboxy, alkylcarboxy, formyl, alkyl-carbonyl, aryl-carbonyl, and heteroaryl-carbonyl;
• R4 and R5 are independently selected from the group consisting of H, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, and substituted aryl-(C1-3)alkyl;
• and,
• n is 2, 3, 4 or 5;
• a compound of formula (IIa) or (IIb):
• wherein in formula (IIa) or (IIb):
• R1 and R2 are independently selected from the group consisting of H, cyano, hydroxyl, amino, acetamido, halo, alkoxy, nitro, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, substituted aryl-(C1-3)alkyl, carboxy, alkylcarboxy, formyl, alkyl-carbonyl, aryl-carbonyl, and heteroaryl-carbonyl;
• R3 and R4 are independently selected from the group consisting of H, C1-6 alkyl, aryl, heteroaryl, and substituted C1-6 alkyl;
• R5 is selected from the group consisting of H, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, and substituted aryl-(C1-3)alkyl;
• and,
• m is 1, 2, 3 or 4;
• 2,7-diamino-5-(4-fluorophenyl)-4-oxo-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile;
• (Z)-2-(1H-benzo[d]imidazol-2-yl)-N′-hydroxy-3-(4-methoxyphenyl)propanimidamide;
• mixtures thereof, or a pharmaceutically acceptable salt thereof.

A method of treating, ameliorating or preventing Parkinson's Disease in a patient, the method comprising administering to the patient a therapeutically effective amount of at least one compound selected from the group consisting of:

• a compound of formula (I):
• wherein in formula (I):
• R1, R2 and R3 are independently selected from the group consisting of H, cyano, hydroxyl, amino, acetamido, halo, alkoxy, nitro, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, substituted aryl-(C1-3)alkyl, carboxy, alkylcarboxy, formyl, alkyl-carbonyl, aryl-carbonyl, and heteroaryl-carbonyl;
• R4 and R5 are independently selected from the group consisting of H, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, and substituted aryl-(C1-3)alkyl;
• and,
• n is 2, 3, 4 or 5;
• a compound of formula (IIa) or (IIb):
• wherein in formula (IIa) or (IIb):
• R1 and R2 are independently selected from the group consisting of H, cyano, hydroxyl, amino, acetamido, halo, alkoxy, nitro, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, substituted aryl-(C1-3)alkyl, carboxy, alkylcarboxy, formyl, alkyl-carbonyl, aryl-carbonyl, and heteroaryl-carbonyl;
• R3 and R4 are independently selected from the group consisting of H, C1-6 alkyl, aryl, heteroaryl, and substituted C1-6 alkyl;
• R5 is selected from the group consisting of H, C1-6 alkyl, substituted C1-6 alkyl, heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, aryl-(C1-3)alkyl, and substituted aryl-(C1-3)alkyl;
• and,
• m is 1, 2, 3 or 4;
• 2,7-diamino-5-(4-fluorophenyl)-4-oxo-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile;
• (Z)-2-(1H-benzo[d]imidazol-2-yl)-N′-hydroxy-3-(4-methoxyphenyl)propanimidamide;
• mixtures thereof, or a pharmaceutically acceptable salt thereof.