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US 2022/0204601 A1Published application
Anti-tau antibody and use of same
AssigneeAdel Inc.
InventorSeung-Yong YOON
Life of this patent
Estimating the term…
Abstract
An anti-tau antibody according to the present invention specifically binds to a tau protein, in which the 280th lysine is acetylated. The antibody can inhibit aggregation of abnormal tau proteins. The antibody can improve the motor function and cognitive function of animal models. It can be effectively used for preventing or treating a degenerative neurological disease.
Claims20
An anti-tau antibody or an antigen-binding fragment thereof, comprising:
- a heavy chain variable region (VH) that includes:
- a heavy chain CDR1 having the amino acid sequence represented by SEQ ID NO:
- 1;
- a heavy chain CDR2 having the amino acid sequence represented by SEQ ID NO:
- 2;
- and
- a heavy chain CDR3 having the amino acid sequence represented by SEQ ID NO:
- 3, and
- a light chain variable region (VL) that includes:
- a light chain CDR1 having the amino acid sequence represented by SEQ ID NO:
- 4;
- a light chain CDR2 having the amino acid sequence represented by SEQ ID NO:
- 5;
- and
- a light chain CDR3 having the amino acid sequence represented by SEQ ID NO:
- 6.
13 more elements
A hybridoma having accession number KCTC 14155BP.
Dependencies are inferred from the claim text.