Process for preparation of halogenated benzylamine and intermediates therof
AssigneeSRF Limited
InventorsAmardeep SINGH, Bhupender SINGH, Ram SINGH, Rajender KUMAR, Ajay Kumar CHAUDHARY, Kapil KUMAR, Anurag JAIN
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Abstract
The present invention provides an improved process for the preparation of halogenated benzylamine having the formula I from halogenated benzonitriles, Formula I wherein, X1 is selected from group consisting of hydrogen, chloro or fluoro, provided at least one X1 is chloro or fluoro.
Claims9
A process for preparation of halogenated benzylamine of formula I,
- wherein, X1 is selected from hydrogen, chloro and fluoro, provided at least one X1 is chloro or fluoro,
- said process comprising the steps of:
- a) selective dehalogenation of halogenated benzonitrile of formula III,
- wherein, X1 is selected from hydrogen, chloro and fluoro, provided at least one X1 is chloro or fluoro;
- X2 is selected from chloro or bromo;
- using a transition metal catalyst in presence of an alkanoic acid to obtain a halogenated benzonitrile of formula II,
- wherein X1 is selected from hydrogen, chloro or fluoro, provided at least one X1 is chloro or fluoro;
- and
- b) hydrogenating halogenated benzonitrile of formula II using hydrogenating catalyst and ammonia in presence of a solvent to obtain a halogenated benzylamine of formula I.
A process for preparation of halogenated benzylamine of formula I comprising a step of hydrogenating halogenated benzonitrile of formula II being carried out by continuous addition of halogenated benzonitrile of formula II to a mixture of hydrogenating catalyst, ammonia and solvent.
Dependencies are inferred from the claim text.