Composition for delivery of genetic material
AssigneeOxford University Innovation Limited
InventorsYiqi SEOW, Lydia ALVAREZ, Matthew WOOD
Life of this patent
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Abstract
The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.
Claims11
A method of making a pharmaceutical composition, comprising loading exosomes with a therapeutic oligonucleotide having a chemically modified backbone by transfection of the exosome with a transfection reagent, thereby making the pharmaceutical composition.
A method of delivering a therapeutic oligonucleotide having a chemically modified backbone in vivo comprising delivering the pharmaceutical composition to a selected tissue or cell type, wherein the pharmaceutical composition comprises an exosome that includes exogenous genetic material transfected into the exosome by a transfection reagent, wherein the exogenous genetic material is the therapeutic oligonucleotide having the chemically modified backbone.
A method of treatment by gene silencing or gene therapy comprising administering to the patient in need thereof, an effective amount of the pharmaceutical composition, wherein the pharmaceutical composition comprises an exosome that includes exogenous genetic material transfected into the exosome by a transfection reagent, wherein the exogenous genetic material is a therapeutic oligonucleotide having a chemically modified backbone.
Dependencies are inferred from the claim text.