Fc Receptor-ACE2 Conjugates and Use Thereof
AssigneeCity of Hope
InventorsJohn C. WILLIAMS, Miso PARK
Life of this patent
Estimating the term…
Abstract
Provided herein are, inter alia, peptides capable of binding viral proteins and thereby preventing viral infection, replication and spread (e.g., SARS CoV-2). The conjugates provided herein include an dimerizing domain (e.g., Fc domain) attached through a peptide linker to a protein domain (viral protein binding domain). The viral protein binding domain is capable of binding a viral protein, for example, a viral envelope protein or a portion thereof.
Claims31
A peptide comprising a dimerizing domain bound to a viral protein binding domain through a chemical linker, wherein said viral protein binding domain is bound to the C-terminus of said dimerizing domain.
(canceled)
(canceled)
(canceled)
-15. (canceled)
(canceled)
-25. (canceled)
(canceled)
-34. (canceled)
-53. (canceled)
A peptide complex comprising:
- (i) a first peptide comprising a first dimerizing domain bound to a first viral protein binding domain through a first chemical linker, wherein said first viral protein binding domain is bound to the C-terminus of said first dimerizing domain;
- and
- (ii) a second peptide comprising a second dimerizing domain bound to a second viral protein binding domain through a second chemical linker, wherein said second viral protein binding domain is bound to the C-terminus of said second dimerizing domain;
- wherein said first dimerizing domain and said second dimerizing domain are bound together thereby binding said first peptide to said second peptide.
(canceled)
(canceled)
Dependencies are inferred from the claim text.