Compound used as kinase inhibitor and application thereof

A compound represented by formula I, or a tautomer thereof, or a mesomer thereof, a racemate thereof and a mixture of the mesomer and the racemate thereof, or an enantiomer thereof, a diastereomer thereof and a mixture of the enantiomer and the diastereomer thereof, or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof:

• in formula I:
• A is
• wherein X is independently selected from the group consisting of NR6, O, CR1R2, S, S(O) and S(O)2;
• B is selected from the group consisting of monocyclic aromatic hydrocarbon, bicyclic aromatic hydrocarbon, monocyclic heteroaromatic hydrocarbon and bicyclic heteroaromatic hydrocarbon, wherein, H on any carbon atom of B is optionally substituted by the following substituents:
• halogen, hydroxy, amino, cyano, acyl, ester, alkyl, cycloalkyl, alkylamino, alkoxy, cycloalkoxy, aryl, heteroaryl, monosubstituted or polysubstituted alkyl, monosubstituted or polysubstituted alkoxy, monosubstituted or polysubstituted cycloalkyl, monosubstituted or polysubstituted cycloalkoxy, monosubstituted or polysubstituted aryl, monosubstituted or polysubstituted heteroaryl;
• the substituents of the monosubstituted or polysubstituted alkyl, the monosubstituted or polysubstituted alkoxy, the monosubstituted or polysubstituted cycloalkyl, the monosubstituted or polysubstituted cycloalkoxy, the monosubstituted or polysubstituted aryl, and the monosubstituted or polysubstituted heteroaryl are independently selected from the the group consisting of deuterium, halogen, amino, cyano, hydroxyl, acyl, ester, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, aryl and hetero aryl;
• C is independently
• where Y is independently selected from the group consisting of O, NRA and CR1R2, represents Z shape or E shape;
• wherein R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, amino, cyano, hydroxy, acyl, ester, alkyl, alkoxy, cycloalkyl, aryl, heteroaryl, monosubstituted or polysubstituted alkyl, monosubstituted or polysubstituted alkoxy, monosubstituted or polysubstituted cycloalkyl, monosubstituted or polysubstituted aryl, monosubstituted and polysubstituted heteroaryl;
• the substituents of the monosubstituted or polysubstituted alkyl, the monosubstituted or polysubstituted alkoxy, the monosubstituted or polysubstituted cycloalkyl, the monosubstituted or polysubstituted aryl, and the monosubstituted or polysubstituted heteroaryl are independently selected from the group consisting of deuterium, halogen, amino, cyano, hydroxyl, acyl, ester, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, aryl and heteroaryl;
• or R1 and R2 together with the C atom attached to them form substituted or unsubstituted 3-7 membered cycloalkane, aza-cycloalkane, oxa-cycloalkane or thio-cycloalkane;
• wherein the substituted means being substituted by one or more groups selected from the group consisting of alkyl, acyl, ester, sulfonyl, and sulfinyl;
• R3 and R4 are each independently selected from the group consisting of hydrogen, amino, hydroxy, acyl, ester, alkyl, cycloalkyl, aryl, heteroaryl, monosubstituted or polysubstituted alkyl, monosubstituted or polysubstituted alkoxy, monosubstituted or polysubstituted cycloalkyl, monosubstituted or polysubstituted aryl, and monosubstituted or polysubstituted heteroaryl;
• the substituents of the monosubstituted or polysubstituted alkyl, the monosubstituted or polysubstituted alkoxy, the monosubstituted or polysubstituted cycloalkyl, the monosubstituted or polysubstituted aryl, and the monosubstituted or polysubstituted heteroaryl are independently selected from the group consisting of halogen, amino, cyano, hydroxy, acyl, ester, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, aryl and hetero aryl;
• or R3 and R4 together with the C atom attached to them form substituted or unsubstituted 3-7 membered cycloalkane, aza-cycloalkane, oxa-cycloalkane or thio-cycloalkane or oxo(═O);
• or RA and R4 together with the atom attached to them form substituted or unsubstituted 3-7 membered cycloalkane, aza-cycloalkane, oxa-cycloalkane or thio-cycloalkane;
• or R3 fuses with Y to form substituted or unsubstituted 3-7 membered cycloalkane, aza-cycloalkane, oxa-cycloalkane or thio-cycloalkane;
• wherein the substituted means being substituted by one or more groups selected from the group consisting of alkyl, acyl, ester, sulfonyl, and sulfinyl;
• Z1, Z2, Z3, Z4, Z5, Z6, and Z7 are each independently selected from the group consisting of N, CR5 and NR6;
• R5 is independently selected from the group consisting of hydrogen, halogen, amino, cyano, hydroxy, acyl, ester, alkyl, cycloalkyl, alkylamino, alkoxy, aryl, heteroaryl, monosubstituted or polysubstituted alkyl, monosubstituted or polysubstituted cycloalkyl, monosubstituted or polysubstituted aryl, and monosubstituted or polysubstituted heteroaryl;
• the substituents of the monosubstituted or polysubstituted alkyl, the monosubstituted or polysubstituted cycloalkyl, the monosubstituted or polysubstituted aryl, and the monosubstituted or polysubstituted heteroaryl are independently selected from the group consisting of halogen, amino, cyano, hydroxy, acyl, ester, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, aryl and heteroaryl;
• R6 and RA are each independently selected from the group consisting of hydrogen, acyl, ester, alkyl, cycloalkyl, aryl, heteroaryl, monosubstituted or polysubstituted alkyl, monosubstituted or polysubstituted cycloalkyl, monosubstituted or polysubstituted aryl, and monosubstituted or polysubstituted heteroaryl;
• the substituents of the monosubstituted or polysubstituted alkyl, the monosubstituted or polysubstituted cycloalkyl, the monosubstituted or polysubstituted aryl, and the monosubstituted or polysubstituted heteroaryl are independently selected from the group consisting of halogen, amino, cyano, hydroxy, acyl, ester, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, aryl and heteroaryl.